2013 National Lecture Now Available on YouTube!

One of the highlights of the Biophysical Society’s Annual Meeting is the National Lecture, the highest award given each year. National Lecturers, who are selected by the Society’s President, have the opportunity to talk about their science to the Society at-large, which means giving a talk that is interesting and comprehensible to scientists working in a wide variety of sub-disciplines. In surveys, attendees say that the National Lecture is one of their favorite events at the meeting, and this year was no different. Karolin Luger, Colorado State University, delivered a great talk on “The Making and Breaking of Nucleosomes,” February 4 in Philadelphia, Pennsylvania.

The Society is pleased to be able to share a video recording of that talk with you, as well as past Annual Meeting National Lectures. We encourage individuals unable to attend the meeting to watch the video. We also encourage you to use the lecture as a teaching tool in your classes. Since the talk is more general in nature than most meeting presentations, it is a great resource to introduce a new topic, as well as a successful scientist to students!
We would love to hear how you have used the National Lecture recordings. Please share in the comments below!

Post-Meeting Reflection

Another conference over, another presentation conquered. This being my first Biophysical Society Conference, it was quite an overwhelming experience, the scale of which was unexpected.

Reflecting on whether I achieved my goals when I came to the conference, or whether I find myself in a better position, smarter, faster, etc, I think the answer is unequivocally yes. As I sit in the O’Hare airport at Goose Island (highly recommended if you ever have to kill an hour or two at ORD), I can attest that I made connections, learned about the next step I want to take in my project & career, and most importantly, survived my first big conference talk without becoming physically ill.

As a sixth year graduate student, I think the strides made in determining my next step are the most important. I gained insight about how to approach professors for overseas post-docs, what the funding situations are like in various countries, and how to deal with cultural differences with respect and humility. I think this last bit is especially important for us Americans to realize while still in our own country, as we can often feel impatient with second English speakers when they may be having difficulties expressing themselves. Learning a second language is hard, and at least they are trying, and in a new country, which is a lot more than what a lot of us can say.

So with the passing of this most annual of meetings, I hope we can all reflect a little on what we learn, the goals we achieved, and how we can approach meetings in the coming year to get the most out of it, especially when it comes to moving out of our comfort zones.

Until next year!

MENTORSHIP

Hi everyone! Last day at the meeting!!! Time to go back home and start working on all the exciting ideas you have gotten in this conference? I think so 🙂

I hope everyone coming to the national lecture enjoyed the talk of Dr. Karolin Luger about her work on the structure and function of nucleosomes. Besides all the amazing sciences, I appreciated Dr. Luger’s point on mentorship. As a graduate student that has a chance to mentor a number of undergraduate students, I do feel the importance of my job in nurturing and inspiring the new generation of scientists. As a researcher-in-training, I appreciate all the encouragements and supports from all my graduate fellows, postdocs and most importantly, my supervisors. To me, this is the important momentum to push science forward. So if you are a graduate student reading this blog, don’t forget that your job is not to only do good science, but also to encourage and mentor undergraduate students 🙂 !!

As for my schedule today, I will swing by the ROCKY STEPS and Philadelphia Museum of Arts before flying back to Canada. I want to thank the Biophysical Society for bringing us such a great conference with a lot of learning and fun. I enjoyed watching all the biophysicists getting crazy on the dance floor at the reception! I am looking forward to the next meeting in San Francisco with a lot more exciting events!!

If you ever visit Ontario, Canada, please do not hesitate to contact me! If you ever feel interested in mitochondrial transport or membrane protein work, please contact our lab!!

How to do it like a Biophysicist?

With my limited experience of attending the BPS annual meeting, I made certain observations of how biophysicists do things. Please feel free to let me know if my observations are inaccurate!

How to attend talks/poster sessions like a biophysicist?

Run! Just run across the halls, rooms and the ballrooms to make the most of the meeting while going through the schedule to see where to run next!

How to eat like a Biophysicist?

Spend time browsing through all the available food choices (for this meeting: at the Reading terminal market/Chinatown) and then quickly pack your lunch and run to the next talk. Alternatively you can find a nice place to sit and eat while going through the schedule book to figure out what events to attend.

How to walk like a Biophysicist?

Look cool while trying to juggle carrying your backpack, the BPS tote, assorted free stuff and a poster. And don’t forget your badge!

How to dance like a Biophysicist?

Get funky on the dance floor.

Reception and Dance, next year with the BPS Pun Band!

The last time that I was at the BPS Annual Meeting, I was an undergraduate and I was not present for all of the sessions. That being said, I still knew the first thing I wanted to do when I got to grad school was go back. One session I did not get to go to last time was the reception and dance. This year I was able to go and get down and boogie. That was my kind of party and if you see me walking a little stiff today just know that it’s because my calves are sore from last night. What could have made the night even better? How about a band composed entirely of Biophysical Society Members!

Working on SNARE? Now you’re a drum player!

Enjoy Single Molecule FRET? Lead guitarist!

Do you probe the intricacies of life using SAXS? Now you lead the horn section!

Advancing science with Photo-acoustics? Now you’re our singer!

After getting up at 6:30 for the past couple of days to make (amazing) morning lectures and staying late into the night for just as great night workshops, it was definitely fun to have a drink, dance to a great band, and lead a conga line or two. Hope you all enjoyed the party as much as I, and if my goal was to sweat out all my calories consumed in Philadelphia then I am sure I succeeded.

Pre-Presentation DANCING!

Well, here we are, we’ve made it to the final day of the conference! And for me, that means the day of reckoning has arrived… I give my presentation today!

My general tactic is going to be to stay hydrated (don’t want that dry mouth feeling), and most important, try to get excited. This is a tactic I developed earlier in graduate school to try to mimic the feeling I would get before tests: I would get excited and was overwhelmed with feelings of being totally prepared and ready to take this test on, so give it to me! Needless to say, this is a somewhat harder feeling to force, but the brain is quite a pliable object, and so I can believe it can be done. Instead of letting the nervous energy dissipate in jitters and shaking hands, etc, why not smile and dance!

Of course, it isn’t recommended to try this tactic In the actual presentation room, but I think you get the point. I’ll let you know how it all goes down afterwards, but for now, I’m going to come on, smile, get happy, do a little dance, and practice my slides another 50 times! See ya on the other side!

Into the Dome!

For some brief respite from the onslaught of awesome science, I took the opportunity to visit the Biomolecular Discovery Dome (Hall C) – a portable exhibit, sponsored by the Public Affairs Committee. The dome, which resembles a black Styrofoam igloo, is designed to be taken into schools and teach high school students about a variety of difficult-to-grasp topics, from HIV replication to ribosomes.

In the UK we are seeing a rapid increase in demand from the public for science outreach. The Science, Technology, Engineering and Maths Network brings experts from various disciplines into the public eye with school workshops, public lectures and events. Organisations such as these, as well as the week-long Cambridge Science Festival, are both significant demonstrations of the public’s thirst for knowledge. This demand places the scientists willing to communicate their research at a critical interface between the lab and the lecture hall.

The discovery dome is a well executed example of how public engagement can inspire the next generation of bioscientists and galvanise other members of the public to learn more about the world around them. The dome will be going on the road later this year so go and have a look!

The Biomolecular Dome – Biophysics up close and personal!

The 15-minute experience is well worth it!

You enter an inflatable womb-like dome; you lie down and are taken on an educational journey fuelled by stunning visuals that bring viruses and cells to life all around you. The science is explained concisely through very clear narratives that span a variety of topics:

Viruses for Good and Evil

Ribosomes: Crossroads of Biology, Chemistry and Mechanics

NANOPLANET: An Expedition to the Cell

The Rod Sensory Cilium and Its Disruption in Retinal Neurodegeneration

How HIV Replicates

Tryapanosomes: Their Flagella and How They Move

Which were your favourites? Mine had to be learning about ‘How HIV replicates’ while listening to Nine Inch Nails!

FREE STUFFS!!!!

I can’t imagine how fast time flies. It is already the third day of the conference and things are getting better and better.  Did I mention about the FREE STUFFS you can get at the exhibition? Oh yah, FREE STUFFS… Here is the list of FREE STUFFS that I have in my bag right now: 3 T-shirts, nice calendars, magnets, wristbands, and tons of pens…!  And don’t forget to attend the National Lecture tonight followed by the Reception with FREE DRINKS (well, at least 2 drink tickets anyway :))

So I figured that in a big meeting like this, there are many interesting talks happening at the same time and you might miss a few talks that you wanted to attend. Thus, I will update all of us with some interesting talks that I attended and hopefully, you will find some of them useful.

SCIENCE UPDATE

DAY 1: BIOENERGETIC SUBGROUP (morning) – MITOCHONDRIAL CALCIUM SIGNALING: NEW INSIGHTS AFTER MOLECULAR IDENTIFICATION OF THE CALCIUM UNIPORTER (MCU)

A large portion of the subgroup discussion in the morning focused on the discovery of MCU (pore forming unit) and MICU1 (a key regulatory partner), and their role in Ca2+ uptake in the mitochondria. These Ca2+ uptake events are essential for controlling the metabolic coupling, regulation of cell death, and Ca2+ homeostasis.  The discussion focused on a wide range of techniques used to understand these pathways, including computational, molecular biology, and physiological techniques. But don’t forget that MCU might not be the sole Ca2+ transporter; there are many additional Ca2+ uptake pathways, including rapid mode of uptake (RaM) and type 1 ryanodine receptor (mRyR1). Thus, a picture is more complex and I am sure that more new exciting news will come in the near future.

DAY 2: AUTOMATED CIRCULAR DICHROISM (CD) SPECTROSCOPY – A NEW WAY IN MEDIUM-THROUGHPUT ANALYSIS OF PROTEIN CONFORMATION

This was a talk by Sebastian Fiedler (from Dr. Sandro Keller’s lab) during the Protein Conformation Platform session.  As all of us that are currently working with CD spectroscopy, we are aware that this is a very good method in estimating protein conformation, but rather time-consuming and require human attendance and care in cuvette cleaning. A new automated CD (ACD) setup described by Sebastian allows unattended, serial data acquisition on up to 384 samples and automated cell cleaning. They also took it to the next step in using this technique for quantifying the unfolding event of protein. If you are interested in their work and the ACD technology, please click here.

NON-SCIENCE UPDATE

Patrick at USS New JerseySo I managed to sneak out of the meeting at lunch yesterday to take a short tour to visit the Battleship New Jersey. The USS New Jersey is American’s most decorated battleship, These battle stars were collected from ample services in the WWII, Korean War, Vietnam War, Lebanon and Persian Gulf region. I had a great time there and learned a bit more about US History!!

That is it from me for now!!! Remember, the Annual Meeting Reception is tonight after the National Lecture, and you have 2 drink tickets! Use them 🙂 !! If you don’t want to use them, fee free to stop by my poster today (B434, at 1:45 PM) and I will be more than happy to take them :)!!

Ps: BALTIMORE WON :)!!!!

Imaging revolutionized the way we look the cells

Microscopes let us shoot the fascinating mciro-world normally invisible to human eye. The scopes help us to bring small things at bigger scale. They have completely transformed cell biology, uncovering an array of complex internal structures and emphasising biological differences across multiple organisms. The earliest microscopic device invented by Zacharias Jansen in 1595 was pretty simple; a tube with two glass lenses at one end using light to give a magnification ten times the actual size. During the 17th Century magnification and image quality of light microscopes improved, but were ultimately limited by the wavelength and diffraction properties of visible light.

However, the innovation of fluorescence microscopy over the last 10 years has totally transformed how scientists use light microscopy to study cell structure. Fluorescence microscopy is a highly sensitive technique and an extremely powerful tool in cell biology, but standard microscopes are still limited by their optical resolution. Recently, however, it was discovered that by imaging individual fluorescent molecules separately over time (using special photoactivatable dyes), a fluorescently tagged specimen can be imaged at much higher resolution than previously possible. Termed super resolution microscopy, this technique made it possible to identify single molecules to an accuracy of 25 nanometers inside live cells for the first time.

Today, I really excited and looking forward to Symposium: Imaging from Molecules to Organisms @ 8:15 am to 10:30 am in Grand Ballroom B.  The topics these mornings are

SINGLE MOLECULE FLUORESCENCE AND OPTICAL TRAPS APPLIED TO MOLECULAR MOTORS: TWO CAN DO IT BETTER THAN ONE.
MULTISCALE IMAGING OF TISSUE MECHANICS.
PHOTOACOUSTIC MOLECULAR IMAGING AND ITS BIOPHYSICAL APPLICATIONS.

SUPER-RESOLUTION FLUORESCENCE IMAGING BY STORM.

I hope to meet like minded people and interact more on microscopy and imaging techniques.