My name is Manuel Castro, I am a rising senior at Arizona State University, and my major is Biochemistry with a focus in medicinal chemistry. From a relatively young age, I knew that my love of science was considerably broad. I enjoy the fields of chemistry, biology, and physics; through undergraduate lab research opportunities, I became more familiar with the interdisciplinary concept of biophysics, and subsequently, the breadth and depth associated with this area of study. When my lab mentor told me about the Biophysical Society Summer Research Program, I enthusiastically applied.
At Arizona State, I work in an NMR lab that focuses on characterizing the structure and function of membrane proteins. Under Dr. Wade Van Horn, my work in his lab has helped direct me towards achieving a career within the large realm of biophysics; namely, structural biology. Upon receiving my acceptance letter to the BPS Summer Program, I began looking into various professors at UNC Chapel Hill that complemented my interests. I quickly found Dr. Matt Redinbo, a professor whose lab also focuses in the structural and chemical biology of proteins involved in human disease, but with X-ray diffraction instead.
Coming from an NMR lab, I entered Dr. Redinbo’s crystallography lab with the intention of exploring the structural biology spectrum more broadly. I really wanted to learn X-ray crystallography first hand to help me decide this coming year where to focus my applications for graduate school programs. I expected my work in Dr. Redinbo’s lab would be very general, including making buffers, cleaning dishes, etc. To my pleasant surprise, the same day I met Dr. Redinbo in person, he already had me setting up crystal trays. Within a few more weeks into the BPS course, I was shadowing graduate students using the x-ray source, which I consider my favorite part of the summer course thus far. In addition to the research, I have learned a lot about scientific communication. We give presentations which help train us for graduate-level coursework by having us present on what their research is about and the direction it is headed.
The program also offers classes that introduce important topics of physical chemistry, biochemistry, molecular biology and biophysics. For those who have taken those classes, the course serves as a wonderful review; for those that have not, it is a fantastic introduction to central themes of biophysical studies. These are formal courses with important feedback such graded assignments and quizzes; however, the courses are not for credit. This promotes a comfortable learning environment for students of all levels of education and disciplines.
Overall, I think that this summer has been one of the best of my life so far. The BPS Summer Program allowed me to travel across the country and make new friends from various fields and interests. I would strongly suggest this internship to anyone who is passionate about science, and I have no regrets when I reflect upon my stay at UNC Chapel Hill.