We appreciate the opportunity to illustrate a new powerful technique, Tip Enhanced Raman Spectroscopy (TERS) as cover art for the Biophysical Journal. TERS, the combination of Atomic Force Microscopy (AFM) and Raman microscopy, provides chemical information with nanometer spatial resolution. The cover image shows a TERS probe, a metal nano particle(s) mounted on an AFM tip, placed near an amyloid fibril. A Raman signal is strongly enhanced in nanometer vicinity of the particle providing vibrational signature of the fibrillar surface. Moving the cantilever allows for mapping the surface and providing structural information relevant to the biological activity and associated toxicity of the fibrils.
The application of TERS for structural characterization of biological species is a new, but quickly developing field. The illustration of TERS on the cover of the Biophysical Journal is an important recognition of the power and uniqueness of this technique. We hope this helps generate interest in TERS and attracts more researchers to this growing field.
–Dmitry Kurouski , Tanja Deckert-Gaudig , Volker Deckert, and Igor Lednev