We are very excited for the opportunity to illustrate our work as cover art for Biophysical Journal. We recognize and value the importance of visual representation in scientific communication and designed the image with a perspective that captures the functional implications of our research findings. The image shows a translucent actin filament viewed down the long filament axis. The green and blue spheres represent filament-associated cations–one of each per filament subunit– that promote filament assembly and enhance mechanical stiffness, respectively. Because the actin is translucent, the radial position of the cations along the filament axis can be readily visualized, revealing its rotational symmetry and organization.
–Enrique De La Cruz, Yale University